Note the association between the development of hereditary hamartomatous lesions in the uterine endometrium and COVID-19 Vaccination

Estrogen, a female hormone, is closely related to the development of many endometrial cancers. Estrogen stimulates the growth of the uterine lining. Therefore, it is known that in women with high estrogen levels, endometrial cancer develops through a premalignant stage called endometrial hyperplasia. Women who have never given birth, are obese, have irregular menstrual cycles (anovulatory menstrual cycles), or are taking estrogen-only hormone therapy have an increased risk of developing endometrial cancer.

On the other hand, there are also cases in which endometrial cancer developed independently of estrogen stimulation. Such endometrial cancer develops due to abnormalities in cancer-related genes.
For example, Cowden syndrome/PTEN hamartoma tumor syndrome is a rare disorder of autosomal dominant inheritance caused by germline pathogenic variants in the PTEN gene. Individuals with pathogenic variants in PTEN have multiple hamartomatous lesions in the gastrointestinal tract, skin, mucosa, breast, thyroid, uterine endometrium, and brain.

Thus, in women with germline pathogenic variants in the PTEN gene, vaccine with mRNA-based COVID-19 vaccination may affect the development of hamartomatous lesions in the uterine endometrium. In clinical practice, irregular menstruation and abnormal bleeding are recognized as symptoms of gynecological malignancies such as uterine endometrial carcinoma. Therefore, gynecologists should deepen their understanding of irregular menstruation and abnormal bleeding due to vaccination with mRNA-based COVID-19 vaccine before performing examinations.

However, endometrial symptoms with COVID-19 mRNA vaccination immediately improve.

Science Published on November 18, 2022. by Kyoto@takumaH

Doctors specializing in cancer medicine/doctors specializing in emerging infectious diseases