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VLP-based Vaccine Development for Coronavirus
Virus-like particle (VLP) is a Polymer nanostructure assembled from natural viral structural proteins, but do not contain any genetic material. The VLP consists of high-density displays of viral surfa
もっとみるADMET Profiling for Coronavirus
A number of computational methods have been used in various aspects of drug discovery and development. In recent decades, in silico ADMET (absorption, distribution, degeneration, excretion, and toxici
もっとみるLead Optimization for Coronavirus
The outbreak of novel coronavirus (SARS-CoV-2, formerly known as 2019-nCoV) has drawn global attention, prompting the urgent need to find specific and broad-spectrum antiviral drugs. With years of exp
もっとみるHit to Lead for Coronavirus
At present, the drug research for treating Coronavirus Disease 2019 (COVID-19) has just started, and there is a lack of selective therapeutic drugs in clinical practice. It is urgent to find and devel
もっとみるCoronavirus Protein Co-crystallization
The necessary condition for successful X-ray crystallographic analysis is to obtain a single crystal of the target protein that meets the X-ray diffraction standard. The data are then collected by X-r
もっとみるCoronavirus Super-resolution Microscopy
Because most viruses are small (<200 nm), standard optical microscopes are generally not suitable for direct observation of them. The use of electron microscopy (EM) to visualize the ultrastructure of
もっとみるCoronavirus-like Particle Super-resolution Microscopy
Because most viruses are small (<200 nm), standard optical microscopes are generally not suitable for direct observation of them. The use of electron microscopy (EM) to visualize the ultrastructure of
もっとみるCoronavirus Scanning Electron Microscopy
Scanning electron microscopy (SEM) is characterized by simple sample preparation, wide adjustable magnitude range, high image resolution, and large depth of field. SEM technology can scan the surface
もっとみるCoronavirus-like Particle Ultra-thin Section EM
The ultra-thin section electron microscopy (EM) technology is an effective means to observe the characteristics of viruses and the interaction between viruses and host cells. Creative Biostructure pro
もっとみるCoronavirus Cryo-ET
Cryo-electron tomography (cryo-ET) is an approach for resolving polymorphic structures such as cells and organelles in a near-natural state and can provide a three-dimensional (3D) snapshot of viral p
もっとみるCoronavirus PPI Analysis
The ongoing outbreak of novel coronavirus (also termed as SARS-CoV-2) poses a challenge for public health. There is an urgent need to understand the molecular mechanism of this viral infection and to
もっとみるADMET Profiling for SARS-CoV-2
A number of computational methods have been used in various aspects of drug discovery and development. In recent decades, in silico ADMET (absorption, distribution, degeneration, excretion, and toxici
もっとみるCoronavirus Vaccine Liposome Technology
Similar to recombinant virus vector vaccines, nucleic acid vaccines (including DNA vaccines and mRNA vaccines) can directly produce pathogen antigen proteins in the human body, which is an emerging va
もっとみるRecombinant Vector Vaccine Development for COVID-19
The emergence and outbreak of emerging infectious diseases is a global challenge to public health. At present, scientists from academia and biopharmaceutical industries around the world are working ha
もっとみるRecombinant Subunit Vaccine Development for COVID-19
Vaccines are powerful weapons against many human diseases, especially infectious diseases. In response to coronavirus infections, Creative Biostructure, with its expertise in structural biology and pr
もっとみるCoronavirus MST Service
Microscale thermophoresis (MST) is a label-free and immobilization-free technique for quantifying biomolecular interactions. It measures the movement of molecules along a microscopic temperature gradi
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