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VLP-based Vaccine Development for Coronavirus

Virus-like particle (VLP) is a Polymer nanostructure assembled from natural viral structural proteins, but do not contain any genetic material. The VLP consists of high-density displays of viral surface proteins and is therefore a highly ad

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    • ADMET Profiling for Coronavirus

      A number of computational methods have been used in various aspects of drug discovery and development. In recent decades, in silico ADMET (absorption, distribution, degeneration, excretion, and toxicity) modeling as a rational drug design t

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      • Lead Optimization for Coronavirus

        The outbreak of novel coronavirus (SARS-CoV-2, formerly known as 2019-nCoV) has drawn global attention, prompting the urgent need to find specific and broad-spectrum antiviral drugs. With years of experience in structure-based drug design (

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        • Hit to Lead for Coronavirus

          At present, the drug research for treating Coronavirus Disease 2019 (COVID-19) has just started, and there is a lack of selective therapeutic drugs in clinical practice. It is urgent to find and develop new treatment methods and drugs. In t

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        VLP-based Vaccine Development for Coronavirus

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          Coronavirus Protein Co-crystallization

          The necessary condition for successful X-ray crystallographic analysis is to obtain a single crystal of the target protein that meets the X-ray diffraction standard. The data are then collected by X-ray diffraction from a single crystal wit

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          Coronavirus Protein Co-crystallization

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          Coronavirus Super-resolution Microscopy

          Because most viruses are small (<200 nm), standard optical microscopes are generally not suitable for direct observation of them. The use of electron microscopy (EM) to visualize the ultrastructure of viruses has become the gold standard fo

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          Coronavirus Super-resolution Microscopy

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          Coronavirus-like Particle Super-resolution Microscopy

          Because most viruses are small (<200 nm), standard optical microscopes are generally not suitable for direct observation of them. The use of electron microscopy (EM) to visualize the ultrastructure of viruses has become the gold standard fo

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          Coronavirus-like Particle Super-resolution Microscopy

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          Coronavirus Scanning Electron Microscopy

          Scanning electron microscopy (SEM) is characterized by simple sample preparation, wide adjustable magnitude range, high image resolution, and large depth of field. SEM technology can scan the surface morphology of the sample by emitting a b

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          Coronavirus Scanning Electron Microscopy

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          Coronavirus-like Particle Ultra-thin Section EM

          The ultra-thin section electron microscopy (EM) technology is an effective means to observe the characteristics of viruses and the interaction between viruses and host cells. Creative Biostructure provides ultra-thin section EM services com

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          Coronavirus-like Particle Ultra-thin Section EM

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          Coronavirus Cryo-ET

          Cryo-electron tomography (cryo-ET) is an approach for resolving polymorphic structures such as cells and organelles in a near-natural state and can provide a three-dimensional (3D) snapshot of viral particles in the host cell environment. T

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          Coronavirus Cryo-ET

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          Coronavirus PPI Analysis

          The ongoing outbreak of novel coronavirus (also termed as SARS-CoV-2) poses a challenge for public health. There is an urgent need to understand the molecular mechanism of this viral infection and to develop effective vaccines and antiviral

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          Coronavirus PPI Analysis

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          ADMET Profiling for SARS-CoV-2

          A number of computational methods have been used in various aspects of drug discovery and development. In recent decades, in silico ADMET (absorption, distribution, degeneration, excretion, and toxicity) modeling as a rational drug design t

          biostructur…

          ADMET Profiling for SARS-CoV-2

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          Coronavirus Vaccine Liposome Technology

          Similar to recombinant virus vector vaccines, nucleic acid vaccines (including DNA vaccines and mRNA vaccines) can directly produce pathogen antigen proteins in the human body, which is an emerging vaccine technology. Creative Biostructure

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          Coronavirus Vaccine Liposome Technology

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          Recombinant Vector Vaccine Development for COVID-19

          The emergence and outbreak of emerging infectious diseases is a global challenge to public health. At present, scientists from academia and biopharmaceutical industries around the world are working hard to find ways to prevent and treat cor

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          Recombinant Vector Vaccine Development for COVID-19

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          Recombinant Subunit Vaccine Development for COVID-19

          Vaccines are powerful weapons against many human diseases, especially infectious diseases. In response to coronavirus infections, Creative Biostructure, with its expertise in structural biology and protein engineering, now provides comprehe

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          Recombinant Subunit Vaccine Development for COVID-19

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          Coronavirus MST Service

          Microscale thermophoresis (MST) is a label-free and immobilization-free technique for quantifying biomolecular interactions. It measures the movement of molecules along a microscopic temperature gradient, which relies on changes of molecula

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          Coronavirus MST Service

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