Hyperphosphatemia - 高リン血症 -

1) Decreased urinary PO4- excretion
・Deceased GFR
・Urinary bladder rupture or urine leakage into tissue
・Hypoparathyroidism
・Acromegaly (increasing tubular PO4- resorption by GH)

2) Increased PO4- absorption from intestine
・phosphate enema or ingestion of phosphate urinary acidifier
・increased vitamin D
・Ischemic intestinal lesions (maybe also shift from ICF to ECF)
※Intestinal lesions requiring intestinal resection : Devitalized intestinal mucosa allow PO4- to enter plasma and peritoneal fluid. Also shifting of PO4- from ICF to ECF may be involved.
・Diet (low Ca:iP ratio) VERY RARE

3) Shift of ICF to ECF
・Myopathies : Rhabdomyolysis, malignant hyperthermia
・Acute tumor lysis syndrome

4) other or unknown mechanism
・Hyperthyroidism in cats
・Lactic acidosis
・Hyperadrenocorticism in dogs

✔︎ The (iP) in growing mammals met be up to 3 mg/dL higher than iP reference intervals for adult cats and dogs.

✔︎Pseudo-hyperphosphatemia (falsely increasing iP)
・hyperbilirubinemia
・monoclonal gammopathy
・in vitro hemolysis