ChatGPT先生はうそをつく; P2X3は有髄神経にもある

Is P2X3 present in the myelinated nerve?

ChatGPT先生

No, P2X3 is not present in the myelinated nerve.

Is P2X3 present in the myelinated nerve?
PERPLEXITY先生

P2X3 is present in both myelinated and unmyelinated nerve fibers[1][2]. It is characterized as a myelinated multi-branching nerve ending[3] and has been associated with neuropathic pain[4] and migraine mechanisms[5].
１）　https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4764453/#:~:text=In contrast%2C P2X3 was found,receptor within vagal afferent terminals.
In contrast, P2X3 was found in myelinated and unmyelinated axons and thus it did not have good predictive value based on fiber type for the localization of this receptor within vagal afferent terminals.
２）https://pubmed.ncbi.nlm.nih.gov/26706222/
In contrast, we found that the ATP-sensitive channel P2X3 is found in a subset of both myelinated and unmyelinated vagal afferent fibers.
３）https://onlinelibrary.wiley.com/doi/10.1002/cne.24351
４）https://www.sciencedirect.com/science/article/pii/S0753332222004188
We cannot exclude that P2X3 or P2X2/3 receptors are also widely expressed along the nonmyelinated C- fibers or located in the nodes of Ranvier of Aδ-fibers analogous to recently proposed location of CGRP receptors [72]. Taken together, these data cast some light on the involvement of P2X3 and P2X2/3 complexes in purinergic mechanisms contributing to trigeminal pain.

早く、BioGPTを試したい

なぜこだわるか・・・以下の記載の説明で「有髄神経のP2X3はどうした？」と思ってしまったのがきっかけ

「リフヌア®錠」は、世界で初めて承認された選択的P2X3　８受容体拮抗薬で、気道の迷走神経のC線維上にみられるP2X3受容体を介した細胞外ATPシグナル伝達の遮断により、感覚神経の活性化及び咳嗽を抑制します。効能又は効果は「難治性の慢性咳嗽」です

https://www.msd.co.jp/news/product-news-20220120/