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WHO:三段階除痛ラダー 2) Yoon YJ, et al: A comparison of efficacy and safety of non-steroidal anti-inflammatory drugs versus acetaminophen in the treatment of episodic tension-type headache: a meta-analysis of randomized placebocontrolled trial studies. Korean J Fam Med, 33: 262-271, 2012[PMID: 23115700] 3) Onda A, et al: Comparison of the effects of treatment with celecoxib, loxoprofen, and acetaminophen on postoperative acute pain after arthroscopic knee surgery: A randomized, parallel-group trial. J Orthop Sci, 21: 172-177, 2016[PMID: 26888227] 4) Bailey E, et al: Ibuprofen and/or paracetamol (acetaminophen) for pain relief after surgical removal of lower wisdom teeth. Cochrane Database Syst Rev: CD004624, 2013[PMID: 24338830] 5) Cooper SA, et al: Comparative analgesic potency of aspirin and ibuprofen. J Oral Surg, 35: 898-903, 1977 [PMID: 269932] 6) McQuay HJ & Moore RA: Dose-response in direct comparisons of different doses of aspirin, ibuprofen and paracetamol (acetaminophen) in analgesic studies. Br J Clin Pharmacol, 63: 271-278, 2007[PMID: 16869819] 7) Thybo KH, et al: Effect of combination of paracetamol (acetaminophen) and ibuprofen vs either alone on patientcontrolled morphine consumption in the first 24 hours after total hip arthroplasty: The PANSAID randomized clinical trial. JAMA, 321: 562-571, 2019[PMID: 30747964] 8) Goldstein J, et al: Acetaminophen, aspirin, and caffeine in combination versus ibuprofen for acute migraine: results from a multicenter, double-blind, randomized, parallel-group, single-dose, placebo-controlled study. Headache, 46: 444-453, 2006[PMID: 16618262] 9) Lipton RB, et al: Caffeine in the management of patients with headache. J Headache Pain, 18: 107, 2017 「イブプロフェン」 は小児に対する解熱効果で 「アセトアミノフェン」 より優れるという報告 (Am J Dis Child, 146: 622-625, 1992 [PMID: 1621668]) はありますが, OTC の 「イブプロフェン」 は小児には使えません. 

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