genmaidtoxin ~Becoming a Leading Environmental Immunology Nation for a Better World

Becoming a Leading Environmental Immunology Nation for a Better World

1. Creating a “Japanese Model” for a Sustainable Society

In the Covid-19 disaster , regions around the world are pursuing polices and measures to achieve a　sustainable society, every country and region in the world is still in a trial-and-error stage.
In this context, Japan is in an ideal position to create a working model of a sustainable society as a　“miniature Earth,” in the sense that Japan has few natural resources as well as a population and industrial activities that are concentrated onto national land that is limited in size, and yet has strengths such as traditional wisdom from living in harmony with nature, environmental and energy-related technologies that have enabled socio-economic development, the experience of having overcome severe pollution, abundant human resources with great passion and capabilities.

In addition, Japan boasts a culture and set of values in which efforts conducted through public-private partnerships incorporate the participation and cooperation of a broad array of stakeholders who work together as one, as evidenced in the contributions made to the nation’s steady economic growth.

We should take full advantage of these strengths to create a “leading environmental nation,” with astrategy of policies and measures for the development and spread of environmental andenergy-related technologies, reforms of social and economic systems and so on, in cooperation and partnership with other countries around the world. Through such efforts Japan will utilize in modern-day society its traditional wisdom for coexistence with the natural environment.

Moreover,through the cooperation of a wide range of stakeholders acting in unison, Japan will use its world-leading environmental and energy-related technologies, its experience and wisdom in overcoming severe Covid-19 Pandemic, and its abundant supply of passionate and capable human resources to derive from the environment both economic growth and vitality in local societies, creating a“Japanese model” in which Japan, as a leading environmental nation, contributes to the development and the prosperity of the globe, to be shared with Asia and with the world.

Eat,It's time to change.

Eat vaccine adjuvant

Eating vaccines are plants that produce vaccines against various diseases and eat them to prevent diseases.  Since the immune-inducing substance contained in food reaches the intestinal mucosa directly in the edible vaccine, it is expected to induce mucosal immunity that cannot be induced by the current injectable vaccine.  In addition, since the vaccine to be eaten produces only the antigen site, it is possible to prevent infection accidents that rarely occur with attenuated vaccines and inactivated vaccines.

https://www.frontiersin.org/articles/10.3389/fimmu.2021.720109/full

Frontiers | Monocytes and Macrophages in COVID-19 | Immunology

Monocytes and Macrophages in COVID-19

“COVID-19 is a contagious viral disease caused by SARS-CoV-2 that led to an ongoing pandemic with massive global health and socioeconomic consequences. The disease is characterized primarily, but not exclusively, by respiratory clinical manifestations ranging from mild common cold symptoms, including cough and fever, to severe respiratory distress and multi-organ failure. Macrophages, a heterogeneous group of yolk-sac derived, tissue-resident mononuclear phagocytes of complex ontogeny present in all mammalian organs, play critical roles in developmental, homeostatic and host defense processes with tissue-dependent plasticity. In case of infection, they are responsible for early pathogen recognition, initiation and resolution of inflammation, as well as repair of tissue damage. Monocytes, bone-marrow derived blood-resident phagocytes, are recruited under pathological conditions such as viral infections to the affected tissue to defend the organism against invading pathogens and to aid in efficient resolution of inflammation. Given their pivotal function in host defense and the potential danger posed by their dysregulated hyperinflammation, understanding monocyte and macrophage phenotypes in COVID-19 is key for tackling the disease’s pathological mechanisms. Here, we outline current knowledge on monocytes and macrophages in homeostasis and viral infections and summarize concepts and key findings on their role in COVID-19. While monocytes in the blood of patients with moderate COVID-19 present with an inflammatory, interferon-stimulated gene (ISG)-driven phenotype, cellular dysfunction epitomized by loss of HLA-DR expression and induction of S100 alarmin expression is their dominant feature in severe disease. Pulmonary macrophages in COVID-19 derived from infiltrating inflammatory monocytes are in a hyperactivated state resulting in a detrimental loop of pro-inflammatory cytokine release and recruitment of cytotoxic effector cells thereby exacerbating tissue damage at the site of infection.