Evertor 5mg tablet - Everolimus | Apple Pharmaceuticals

EVERTOR 5MG

Description
Evertor 5mg consists of an active ingredient known as Everolimus which intrudes with the growth of cancer cell and the process is slowed down. 
Evertor 5mg tablets is not a curable medication, which helps to slow their spreading into the body.

Indication
Primarily Evertor 5mg tablets indicated for the treatment :
* kidney carcinoma
* Breast carcinoma
* Brain carcinoma
Everolimus is also indicated in various advanced stage cancer in stomach, intestines or pancreas.

Mechanism Of Action
Everolimus is an inhibitor of mTOR, joins at high compatibility to FK506 binding protein 12, via producing drug complex that inhibits the productive of mTOR.
This inhibition reduces the activity of effectors downstream, which may lead to stoppage of cell progression from G1 into S phase, Finally causes cell growth arrest and apoptosis

Dosage  
Evertor 5mg tablets should be given with or without food.
Dosage regimen of Evertor 5mg;
In breast cancer, renal cell cancer, pancreatic cancer, Neuroendocrine cancer:
The prescribed dosage is 10mg should be taken as a single dose.
In Brain or intracranial cancer:
The prescribed dosage of Evertor as a single dose. is 4.5mg/m2 given orally 
In pediatric:
The pediatric dosage of Evertor as a single dose in the brain or intracranial tumor is 4.5mg/m2 should be given orally.

Side Effects
Hypersensitivity reactions, Lymphomas & other malignancy, Serious infections, Kidney graft thrombosis, Hepatic artery thrombosis, Nephrotoxicity, Hyperlipemia, Angioedema, Interstitial lung disease, Thrombocytopenia, Male infertility, Proteinuria, New commencement of diabetes.

Pregnancy and lactation
Pregnancy category of Everolimus C.
In patients, Evertor 5mg is used only after knowing the benefits to the mother exceed the risk to a fetus.
Breastfeeding should not be suggested

Storage
Evertor 5mg tablet store at 25°C
Store the medicine away from moisture, heat, and light

Missed Dose
The over dosage of Everolimus is limited If overdosage occurs the patient must be provided with supportive measures. And monitor evidence of toxicity in Everolimus overdosage.

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