Azel 40mg tablet (Enzalutamide) | Apple Pharmaceuticals

AZEL 40MG

Description
Azel 40mg tablets are containing an active substance known as Enzalutamide, which has anti-tumor activity by exhibiting androgen receptor inhibitory activity. Azel 40mg is a nonsteroidal anti-androgen drug; by inhibiting the androgen synthesis and expels anti-neoplastic activity against the prostate tumor. Azel 40mg is an oral tablet form, which is endorsed by the FDA. Enzalutamide is related to a reducing rate of serum enzyme increased during treatment, be that as it may, have not been connected to instances of clinically clear liver damage with jaundice.

Clinical use
The major clinical indication of Azel 40mg is involved in the treatment of long-lasting or metastatic castration-resistant prostate cancer patients who are not responding with docetaxel therapy.

Mechanism Of Action
Androgen is a male hormone; testosterone is one of the hormones secreted from androgen which is responsible for the growth of the tumor cells present in the prostate glands. Azel 40mg tablets are comprised of Enzalutamide which acts by inhibiting the binding of androgen into the androgen receptor site. This inhibition leads to interfering with signal transduction of receptors and causes growth retardation. The active metabolite of Enzalutamide is N-desmethyl Enzalutamide which is similar to the parent form. Azel exhibits an anti-neoplastic effect by reducing cell proliferation leads to cell death and reduce the tumor cell volume.

Dosage  
Generally, Azel is available in the strength of 40mg; the usual dose of Enzalutamide is 160mg taken as once a day. Four Azel 40mg tablets should be taken as such at whole. Azel 40mg tablets should be administered with or without food Do not chew, open or crush the capsules.

Dose Alteration
If the patient accomplished with toxicities with the grade of III, postpone the therapy using with Azel 40mg capsules until changed to grade II. Then continue with the same dose or dose will be reduced to 120mg or 80mg depending upon the condition of the patients. 
In combination with strong CYP2C8 inhibitors, dosage altered as : 
Azel 40mg capsules, CYP2C8 inhibitors combination should be avoided if possible. Co-administration of Azel 40mg capsules with strong CYP2C8 inhibitors, the dose of Azel should be decreased to 80mg as a single dose. After discontinuation of strong CYP2C8 inhibitors, the dose of Azel 40mg capsules should be used as such before the co-administration starts.

Side Effects
Peripheral edema, Back pain, Arthralgia, Musculoskeletal pain, Musculoskeletal stiffness, weakness, Diarrhea, Hot flush, Hypertension, Headache, Dizziness, Mental impairment, Hypoesthesia, Respiratory tract infection, Insomnia, Anxiety, Hematuria, Pollakiuria, Fall associated injuries, Non pathogenic fractures, Pruritus, Dry skin, Epistaxis, Elevation of AST & ALT, Elevation of bilirubin, Sepsis, Hallucination.

Pregnancy
The pregnancy category of Enzalutamide X, which means it, may cause fetal harm even to death. Azel 40mg should not be recommended in pregnancy conditions.

Lactation
Breastfeeding should not be suggested.

Storage
Azel capsules should be stored at 20°C to 25°C. Kept the drug in a dry and cool place. Protect from light.

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