お勉強322：緩和的全肝照射

RCT of SINGLE fraction (8Gy) RT vs. BSC for painful liver metastases.

Patients receiving RT had improved pain on validated assessments. Also trend to improved OS (not powered).

Single fraction RT easy to administer (whole liver), cost effective, & convenient.#GI23 @OncoAlert pic.twitter.com/kHazqhHv80

— Dr. Nina Niu Sanford (@NiuSanford) January 20, 2023

https://twitter.com/loconte/status/1616453292543852546

Very intriguing study presented by Dr Laura Dawson of single whole liver 8Gy radiation for pts with extensive liver mets or HCC with pain given prior to best supportive care significantly improved QOL but also survival #gi23 - radiate before hospice referral? pic.twitter.com/o8t9GRfoZ4

— Noelle LoConte, MD (@loconte) January 20, 2023

いわゆる緩和的全肝照射のIII相試験
候補患者は一番上のツイートの最初の
写真を参考にしてほしいのだが、要は肝機能はそこまで
悪くなっていないが、肝臓がメタメタで痛い人。
全肝に８Gy/1Fr。　症状の改善率も高く、
なによりOSにも影響しそうというのがスゴイ。

Love the patients words here, improving symptoms with palliative RT is one of the most rewarding parts of being a radiation oncologist. #GI23 pic.twitter.com/OovBKxQiQR

— Dr. Nina Niu Sanford (@NiuSanford) January 20, 2023

ここに載っている患者の声も、こんな手紙もらったらマジ嬉しい
日本では駒込病院がまとまった報告を出していたが、
これで日本でさらに広まるといいように思う。