Performance of Novel High-Sensitivity Cardiac Troponin I Assays for 0/1-Hour and 0/2- to 3-Hour Evaluations for Acute Myocardial Infarction: Results From the HIGH-US Study

https://pubmed.ncbi.nlm.nih.gov/32046869/

The 0/1-hour rule-out/rule-in acute myocardial infarction algorithm ruled out 714 patients (33.8%) according to an initial hs-cTnI value less than 3 ng/L. 

The 1-hour D(baseline value <6 ng/L and a 1-hour Dhs-cTnI value <3 ng/L) ruled out an additional 351 individuals (16.6%). 

Overall, 1,065 patients (50.4%) with clinically suspected acute myocardial infarction were ruled out within the first hour of evaluation, with a negative predictive value of 99.7% and a sensitivity of 98.7% (95% CI 99.2% to
99.9% and 96.3% to 99.7%, respectively) (Figure 2A).