Trastuzumab – Hertraz 150mg tablets| Anticancerdrugs

HERTRAZ – 150MG

Describes As :

Hertraz 150mg helps to reduce the rate of reactivation & mortality.
One of the epidermal growth factor receptor is known as human epidermal growth factor receptor 2 (HER2) plays vital role in breast cancer. This factor is responsible for cell replication. Hertraz 150mg injection consist a targeted cancer drug known as Trastuzumab, which is Pharmacologically grouped as humanized monoclonal antibody produced by recombinant DNA technology. This factor is responsible for cell replication.
An FDA approved product Hertraz 150mg which is involved in breast cancer treatment.

Indication :

The medication Hertraz 150mg is indicated for the treatment of following conditions :
Supportive treatment for breast cancer
Advanced breast cancer
Advanced gastric cancer.

Pharmacokinetic :

Distribution:
Volume of distribution: 44 mL/kg as trastuzumab; 3.13 L as trastuzumab emtansine.
Metabolism:
As trastuzumab emtansine: which Undergoes deconjugation and catabolism through proteolysis in cellular lysosomes.
Excretion:
Terminal Elimination half-life is 6 days (weekly dosing); 16 days (3 weekly regimen); approx 4 days as trastuzumab emtansine.
Elimination of drug includes clearance of IgG through the reticuloendothelial system.

Mechanism :

Hertraz 150mg is a type of monoclonal antibody which targeting the HER2, provoke a resistant mediate reaction which causes disguise and down regulation of HER2.This joining leads to antibody mediated and leads to HER2 positive cells break down.
Hertraz 150mg is a intermediary of anti-body dependent cellular cytotoxicity.

Safety Precautions :

Cardiomyopathy :

Hertraz 150mg receiving patients have increased risk of exposing to cardiac disorders.
To overcome the problem by;
Monitoring cardiac functions regularly
Avoid using anthracycline drug after Hertraz 150mg treatment
Provide alternative therapy management.Provide alternative therapy management
In serious condition, treatment should be discontinuing. Infusion reactions;
During Hertraz 150mg treatment some life-threatening infusion reactions are produced.
The manifestation due to infusion reactions should be monitored frequently
Delay the infusion of Hertraz 150mg treatment and Start the supportive measures by providing epinephrine, corticosteroids, diphenhydramine, bronchodilators, & oxygen. Hertraz 150mg is contraindicated to pregnancy period.
Avoid becoming pregnancy during this therapy.
Use efficient contraceptives during treatment Pulmonary toxicity;

Hertraz interact With :

Hertraz 150mg interaction with anthracycline after ending of Hertraz 150mg treatment may have a chance of getting cardiac problem. This side effects occur because of Transtuzumab great disaster period is depends on population PK analysis.Do not take anthracycline treatment for 7 months after stopping the Hertraz 150mg treatment.In some phenomenal condition, patient should get anthracycline, in that situation patient’s cardiac function should be checked carefully with regular intervals.

Pregnancy and lactation :

Hertraz 150mg pregnancy category is D
Hertraz 150mg should not suggest during pregnancy condition.
Breast feeding should not be recommended.

Contraindication :

No possible contraindicated occurs.
Infusion reactions are produced.
The patients are contraindicated to the component present in the Hertraz 150mg, Hence Hypersensitivity reactions are occurring.

Storage :

Hertraz 150mg vials should be stored at refrigerator temperature of 2oC to 8oC. Keep the vial away from heat & light. After reconstitution, vial should be stored at 2oC to 8oC for 28 days. Stored Hertraz 150mg diluted bag at 2oC to 8oC for 24 hours..

Missed dose :

If missed cycles of Hertraz 150mg treatment by one week or less, then the repeated maintenance dose (weekly schedule: 2mg/kg; 3 weekly schedule: 6mg/kg) administer as soon as probably.
Until the next planned cycle the patient does not take interval.If patient missed to take Hertraz 150mg dose by higher than one week, then resume with re-storing dose of Hertraz 150mg such as weekly schedule is 4mg/kg; 3 weekly schedules is 8mg/kg should be administered over period of 90 minutes.

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