Capnat 150mg tablets | Capecitabine | MHP

CAPNAT 150MG
DESCRIPTION:
Capecitabine is classified as an inhibitor of nucleoside side metabolite, in which the mechanism involved in this medicine is inhibiting nucleic acid synthesis.

Capnat 150 mg tablets are containing an active constituent which is under capecitabine which is under the derivative of deoxycytidine and fluorouracil prodrug that is consisting of anti-metabolic activity involved in the therapy of colon cancer cancer & healing

INDICATION:
The primary indication of Capnat 150 mg:
Colon rectal cancer
Breast cancer
Gastric cancer

In colon rectal:
Capnat 150 mg is also indicated for the treatment of colon or rectal cancer which has become worse condition or spread to other body parts. The medication will inhibit colon cancer from spreading in people after the surgery to remove tumors. Capnat 150 mg tablets should be used in combination with docetaxel with an advanced stage patient who are resistant to anthracycline containing chemotherapy.

Image result for breast cancer

Brand: Capnat
Ingredients: Capecitabine
Strength: 150 mg
Manufactured: Natco Pharma Ltd
Package: 60 tablets
PREPARATION:
Liver insufficiency: mild or moderate damages patients Administered Capnat 150 mg regularly before or after the treatment

Embryo fetal toxicity:
Capnat 150 mg causes fetal harm, which may cause death.
Pregnancy: Capnat 150 mg is contraindicated; produce carcinogenesis, mutagenesis, and fertility impairments.

Diarrhea: anti-diarrheal therapy should be provided.

DRUG INTERACTION:
150 mg with anti-coagulant: altered cogulation problem and bleeding occur to controlled this adverse effect; Leucovorin with Capnat 150 mg: 5-FU concentration should be increased, and toxicity elevated by Leucovorin.

150 mg tablets with CYP2C9 substrates: care should be taken for the drug drugs in capnat 150 mg tablets, food and healing Capnat 150 mg should be taken within 30 minutes after meal .. and duration of absorption of Capnat 150 mg occurs.

DOSAGE MANAGEMENT:
Capnat Tablets Should Be Administered On An Empty Stomach, Taken Within 30 Minutes After The Meals.
Dosage Regimens Of Capnat:
The Prescribed Dose Of Capnat Tablets Are 1250 mg / M2 Should Be Administered Orally As Two Times A Day For The Period Of 2 Weeks Pursued By A One-Week Rest Time Given As 3 Weeks Cycle.
In Combination Of Capnat With Docetaxel, The Prescribed Dose Is 1250 mg / M2 Of Capnat As Two Times Day And The Dose Of Docetaxel Are 75Mg / M2 Given As Intravenous Infusion Over The Based
on the docetaxel labeling it should be initiated before starting the docetaxel therapy for the patients getting both Capnat plus docetaxel. period of 1 hour for every 3 weeks .
The usual dose of capnat 1250 mg / m2 should be taken orally for 2 weeks which follows as one-week rest period and the duration of the body of the Duke's C colon cancer patients, the prescribed treatment duration period is 6 months. Be Continue For 3 Weeks Cycle As Total Cycle Is 8 (24 Weeks).
In Case Of Toxicity Occurs Due To Capnat Therapy, Treatment Should Be Interrupt Or Discontinue.
On The Other Way, Dose Adjustment Should Be Suggested To Reduce The Adverse Effect Related To . Toxicity
In Any Drugs That Should Be Combined With Capnat, Must Require Dose Alteration Such As:
. Phenytoin, Coumarin Derivatives Are Combined With Capnat Tablets, Must Undergo Dosage Adjustment
Depending On The Toxicity Grade Of Patients Therapy Should Be Followed:
At First, Patients Suspected With Grade II Toxicity At The Time Of 14 Days Of Capnat Therapy;. The Treatment Should Be Postponed
Therapy Should Be Interrupted Until Grade Changed To I;. Then Therapy With Capnat Should Be Continuing As Same Dose
Supporting Therapy Should Be . Provided If Possible, In Case Of Toxicity
. Grade II Toxicity Sustains In Case Of Combinational Therapy Of Capnat With Docetaxel; Interrupts The Therapy And Toxicity Decreases As Grade 1 Then Continue The Treatment At 100 Pasento Original Dose Of Capnat
In Grade I Toxicity: Continue Dose Of Capnat The
In Grade II;
1St Appearance: Post Pone The Treatment Until Resolved To Grade I And Continue The Therapy With 100 Pasento Dose Of Capnat
2nd appearance: Post treatment with resolved resolved to grade I and continue the therapy with 75% dose of capnat
3rd appearance: Post treated with treatment until resolved resolved to grade I and continue with therapy with 50% dose of capnat.
4th appearance: stop the thesis Treatment of Capnat
In grade III:
1st appearance: Post bone the treatment until resolved to grade I and continue the therapy with 75% dose of Capnat.
2nd appearance: Post bone the treatment until resolved to grade I and continue the therapy with 50% dose . Of Capnat
3Rd Appearance:. Stop The Treatment
In Grade IV:
1St Appearance:. Stop The Treatment Or If Toxicity Resolved To Grade I, Then Resume The Therapy With 50 Pasento Dose Of Capnat
For Hepatic Damage Patients:
. No Dosage Adjustment Should Be Recommended
For Renal Damage Patients:
In Moderate Renal Damage, The Dose Of Capnat Reduced To 75 Pasento In Both Monotherapy Ando Combinational Therapy With Docetaxel
By Using Cockcroft Ando Gault Equation; 140-Age Of Patients X Body Weight In Kg used to analysis the kidney function to obtain creatinine clearance value.

PREGNANCY & LACTATION:
Pregnancy category: D
Capnat 150 mg should not be used in pregnancy and lactation period
The safety and potency of capecitabine should not bee evaluated patients.
The adverse events should be be monitored periodically.

MISSED DOSE:
If you missed the dose, then have it you remember before next dose timing or Missed dose can beswapped
.

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