Redemide 100 mg | Thalidomide | Blueberry pharmacologicals
100 mg Redemide
It Has Been Shown To Be Active In Anti-Angiogenic Activities. It Prevents The Release Of Tumor Necrosis Factor-Alpha From Immunoglobulins And Modulates The Activity Of The Body.
Indication:
Redemide 100 mg Is Used For The Acute Treatment Of The Cutaneousmanifestations Of Moderate To Severe Erythema Nodosum Leprosum (ENL)
. Redemide 100mg Is Not Used As Monotherapy For Such ENL Treatment In The Presence Of Moderate To Severe Neuritis Redemide 100 mg In Combination With Dexamethasone Redemide 100 mg is also used as maintenance therapy for inhibition and suppression of the cutaway manifestoes of ENL relapsed. is indicated for the treatment of patients with newly diagnosed multiple myeloma.
Mechanism:
The immunological effects of underestimated conditions under different conditions but may be related to overgrowth tumors Necrosis factor-alpha (TNF-a) production and down-regulation of selected cell surface adhesion molecules Since cancer patients have a level of TNF-a in patients with ENL, however, it has also been shown to increase plasma TNF-a levels in HIV-seropositive patients. inhibitor.
Pharmacokinetic:
Absorption:
Time to peak plasma concentration is 2.9 to 5.7 hours
Distribution:
plasma protein binding is 55% and 66% for the (+) R and (-) Senantiomers, respectively
Metabolism:
Metabolized Hepatically by enzymes of the cytochrome P450 enzyme system.
Elimination:
Excreted in the urine as unchanged drug is less than 0.7% of the dose. Half-life of thalidomide is 5 to 7 hours.
Side Effects:
• Teratogenicity
• Venous and arterial thrombobolism •
Increased Mortality
• Drowsiness and somnolence
• Peripheral neuropathy
• Dizziness and orthostatic hypotension
• Neutropenia
• Thrombocytopenia
• Increased HIV viral load
• Bradycardia
• Seizures
Drug Interaction:
Interaction Of Redemide 100 mg Tablets With Cardiovascular Medication Will Cause An Additive Bradycardic Effect And Should Be Used With Caution
Combination With Bortezomib, Amiodarone, Cisplatin, Docetaxel, Paclitaxel, Vincristine Etc Will Cause Peripheral Neuropathy And Should Be Used With Caution
Concomitant
Contraindication:
Hypersentivity
Pregnancy – The drug cause risk to fetal. Use of Redemide 100 mg with opioids, antihistamines, antipsychotics, anti-anxiety agents, other CNS depressants .
Pregnancy:
Pregnancy Category X:.. Redemide 100 mg May Cause Risk To Fetal When Administer To A Pregnant Woman This Drug Should Not Administer To A Pregnant Woman Or A Woman Who Aims To Become Pregnant If A Woman Becomes Pregnant During Redemide Therapy, The Drug Must be discontinued immediately, and the woman given correct counselling.
Lactation:
There Has No Data Available For The Presence Of Redemide 100 mg In Human Milk And Effects Of Drug On Breastfed Infants Avoid Breastfeeding During Treatment With Redemide 100 mg.
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