Oncothal 100mg Tablets| Thalidomide | Millionpharma
ONCOTHAL 100MG
Description :
Oncothal 100mg is a prescription drug which is used under supervision of medical oncologist. Oncothal 100mg is a sedative drug discovered at the end of the 50s, which caused a worldwide tragedy. The drug has been prescribed to many pregnant women to relieve pregnancy nausea.Thalidomide is sold under brand name Oncothal.
Indication :
Oncothal 100mg isan antitumor medication Used for the treatment in interaction with dexamethasone of patients with newly diagnosed multiple myeloma and been investigation for indication in various cancer condition like renal cell carcinoma, glioblastoma multiforme and Waldenström’s macroglobulinemia used for the treatment of skin lesions along with leprosy.
Mechanism :
Thalidomide may also change the production and activity of cytokines (growth factors) containing in the growth and survival of certain cancer cells. There may be an effect on the genes which direct the cell’s development and activity specific forthose analogues to cytokines (growth factors), apoptosis (cell death), and metabolism.Thalidomide is known to have numerous effects on the immune system (immunomodulatory agent), which may provide to its therapeutic effect.
Adme properties :
The drug Oncothal Metabolized hepatically by enzymes of the cytochrome P450 enzyme system.
Excreted in the urine as unchanged drug is less than 0.7% of the dose.
Half-life of thalidomide is 5 to 7 hours.
The drug Oncothal has Plasma protein binding is 55% and 66% for the (+) R and (-) S enantiomers, respectively.
Dosage management :
The prescribed dose for Multiple Myeloma is 200mg PO qHS in 28-day cycles
Dexamethasone 40mg should administer on days 1-4,9-12,17-20 of 28 days.
The starting prescribed dose for Erythema Nodosum leprosumis 100-300 mg PO qHS.
If moreserious reaction then may initial at 400mg. enhance until active signsdiminish, at least 2 weeks then titrate down by 50 mg increment q 2-4 weeks.
Precautions :
• Starting before Oncothal treatment, make sure to inform doctor about any other medications you are taking (containing prescription, over-the-counter, vitamins, herbal remedies, etc.). do not use aspirin, or products contains aspirin until the doctor especially permits this.
• Avoid administer drugs which may cause drowsiness without first consulting your health care provider. Also avoid alcohol.
• In case of both men and women use contraceptives, and do not get pregnant while taking Oncothal. severe, life-threatening birth defects may have resulted with even one 50mg dose. Methods of contraception has two types, such as latex condoms and spermicides, are needed.
• While taking this Oncothal therapy avoid breast feed.
Drug Interaction :
Combination of Oncothal 100mg with cardiovascular medication will cause an additive bradycardic effect and should be used with caution.
Combination with bortezomib, amiodarone, cisplatin, docetaxel, paclitaxel, vincristine etc will cause peripheral neuropathy and should be used with caution.
When combination of hormonal contraceptives further increases the risk of thromboembolism with Oncothal is Unknown condition.
Pregnancy :
Pregnancy category X
Avoid Oncothal 100mg administer to a pregnant woman or a woman who aims to become pregnant.
Oncothal 100mg may cause fetal harm when administer to a pregnant woman.
If a woman becomes pregnant during Oncothal therapy, the drug must be stop immediately, and the woman given correct counselling.
For More Information :
Call us: +91-9940472902
Mail to : millionhealthpharmaceuticals@gmail.com